Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys
Fenwick, Craig; Turelli, Priscilla; Duhoo, Yoan; Lau, Kelvin; Herate, Cécile; Marlin, Romain; Lamrayah, Myriam; Campos, Jérémy; Esteves-Leuenberger, Line; Farina, Alex; Raclot, Charlène; Genet, Vanessa; Fiscalini, Flurin; Cesborn, Julien; Perez, Laurent; Dereuddre-Bosquet, Nathalie; Contreras, Vanessa; Lheureux, Kyllian; Relouzat, Francis; Abdelnabi, Rana; Leyssen, Pieter; Lévy, Yves; Pojer, Florence; Stahlberg, Henning; Le Grand, Roger; Trono, Didier; Pantaleo, Giuseppe
2023
Abstract
Due to the rapid evolution of SARS-CoV-2 to variants with reduced sensitivity to vaccine-induced humoral immunity and the near complete loss of protective efficacy of licensed therapeutic monoclonal antibodies, we isolated a potent, broad-spectrum neutralizing antibody that could potentially provide prophylactic protection to immunocompromised patient populations.
Details
Title
Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys
Author(s)
Fenwick, Craig ; Turelli, Priscilla ; Duhoo, Yoan ; Lau, Kelvin ; Herate, Cécile ; Marlin, Romain ; Lamrayah, Myriam ; Campos, Jérémy ; Esteves-Leuenberger, Line ; Farina, Alex ; Raclot, Charlène ; Genet, Vanessa ; Fiscalini, Flurin ; Cesborn, Julien ; Perez, Laurent ; Dereuddre-Bosquet, Nathalie ; Contreras, Vanessa ; Lheureux, Kyllian ; Relouzat, Francis ; Abdelnabi, Rana ; Leyssen, Pieter ; Lévy, Yves ; Pojer, Florence ; Stahlberg, Henning ; Le Grand, Roger ; Trono, Didier ; Pantaleo, Giuseppe
Published in
Journal of Infection
Date
2023
Laboratories
LVG
Record Appears in
Scientific production and competences > SV - School of Life Sciences > GHI - Global Health Institute > LVG - Laboratory of Virology and Genetics
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2023-10-23