Inhalation exposure to elevated concentrations of airborne particulate matter is a public health concern. Assessment of exposure can be enhanced through better knowledge of source-receptor relationships, which can be characterized through the inhalation intake fraction metric. This case study provides new insights on variations in particle inhalation intake fractions for indoor sources associated with common human activities in residential buildings. In a controlled climate chamber (air temperature: 24 & PLUSMN; 1 degrees C, relative humidity: 50 & PLUSMN; 5%), we investigated size-resolved intake fractions for particles in relation to four scripted activities performed by a human volunteer: sitting, walking, cooking, and vacuuming. We measured size- and time-resolved particle number concentrations at the volunteer's breathing zone to characterize intake fractions. In addition, we measured particles at four different stationary locations across the climate chamber to assess the degree of spatial heterogeneity in particulate matter concentrations. The results show that particles released from human skin and clothing during sitting were associated with the highest total inhalation intake fraction (13%o), followed by cooking (9%o), vacuuming (5.7%o), and walking (3.9%o). These results highlight how breathing zone proximity to localized emission sources and low indoor air mixing can enhance inhalation exposure to particles. Sitting and cooking caused a maximum inhalation intake fraction in the size range of 1-3 & mu;m. Findings also show that the assumption of a perfectly mixed environment could lead to an underestimation of the inhalation intake of particles by up to 3.2-fold. The results of this case study provide a basis for achieving more accurate personal inhalation exposure assessment and improved indoor air quality management.