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  4. A Rapidly Responsive Sensor for Wireless Detection of Early and Mature Microbial Biofilms
 
research article

A Rapidly Responsive Sensor for Wireless Detection of Early and Mature Microbial Biofilms

Shafaat, Atefeh
•
Gonzalez-Martinez, Juan Francisco
•
Silva, Wanderson O.
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August 25, 2023
Angewandte Chemie International Edition

Biofilm-associated infections, which are able to resist antibiotics, pose a significant challenge in clinical treatments. Such infections have been linked to various medical conditions, including chronic wounds and implant-associated infections, making them a major public-health concern. Early-detection of biofilm formation offers significant advantages in mitigating adverse effects caused by biofilms. In this work, we aim to explore the feasibility of employing a novel wireless sensor for tracking both early-stage and matured-biofilms formed by the medically relevant bacteria Staphylococcus aureus and Pseudomonas aeruginosa. The sensor utilizes electrochemical reduction of an AgCl layer bridging two silver legs made by inkjet-printing, forming a part of near-field-communication tag antenna. The antenna is interfaced with a carbon cloth designed to promote the growth of microorganisms, thereby serving as an electron source for reduction of the resistive AgCl into a highly-conductive Ag bridge. The AgCl-Ag transformation significantly alters the impedance of the antenna, facilitating wireless identification of an endpoint caused by microbial growth. To the best of our knowledge, this study for the first time presents the evidence showcasing that electrons released through the actions of bacteria can be harnessed to convert AgCl to Ag, thus enabling the wireless, battery-less, and chip-less early-detection of biofilm formation.

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Type
research article
DOI
10.1002/anie.202308181
Web of Science ID

WOS:001054098300001

Author(s)
Shafaat, Atefeh
Gonzalez-Martinez, Juan Francisco
Silva, Wanderson O.
Lesch, Andreas
Nagar, Bhawna  
da Silva, Zita Lopes
Neilands, Jessica
Sotres, Javier
Bjorklund, Sebastian
Girault, Hubert  
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Date Issued

2023-08-25

Publisher

Wiley-VCH Verlag GmbH

Published in
Angewandte Chemie International Edition
Article Number

e202308181

Subjects

Chemistry, Multidisciplinary

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Chemistry

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chip-less wireless sensing

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inkjet printing

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mediated electron transfer

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microbial biofilm

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near field communication

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extracellular electron-transfer

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fuel-cells

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silver

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challenges

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reduction

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bacteria

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model

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

Available on Infoscience
September 11, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/200583
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