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research article

Axial and radial axonal diffusivities and radii from single encoding strongly diffusion-weighted MRI

Pizzolato, Marco  
•
Canales-Rodriguez, Erick Jorge  
•
Andersson, Mariam
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March 1, 2023
Medical Image Analysis

We enable the estimation of the per-axon axial diffusivity from single encoding, strongly diffusion-weighted, pulsed gradient spin echo data. Additionally, we improve the estimation of the per-axon radial diffusivity compared to estimates based on spherical averaging. The use of strong diffusion weightings in magnetic resonance imaging (MRI) allows to approximate the signal in white matter as the sum of the contributions from only axons. At the same time, spherical averaging leads to a major simplification of the modeling by removing the need to explicitly account for the unknown distribution of axonal orientations. However, the spherically averaged signal acquired at strong diffusion weightings is not sensitive to the axial diffusivity, which cannot therefore be estimated although needed for modeling axons - especially in the context of multi-compartmental modeling. We introduce a new general method for the estimation of both the axial and radial axonal diffusivities at strong diffusion weightings based on kernel zonal modeling. The method could lead to estimates that are free from partial volume bias with gray matter or other isotropic compartments. The method is tested on publicly available data from the MGH Adult Diffusion Human Connectome project. We report reference values of axonal diffusivities based on 34 subjects, and derive estimates of axonal radii from only two shells. The estimation problem is also addressed from the angle of the required data preprocessing, the presence of biases related to modeling assumptions, current limitations, and future possibilities.

  • Details
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Type
research article
DOI
10.1016/j.media.2023.102767
Web of Science ID

WOS:000991931500001

Author(s)
Pizzolato, Marco  
Canales-Rodriguez, Erick Jorge  
Andersson, Mariam
Dyrby, Tim B.
Date Issued

2023-03-01

Publisher

ELSEVIER

Published in
Medical Image Analysis
Volume

86

Article Number

102767

Subjects

Computer Science, Artificial Intelligence

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Computer Science, Interdisciplinary Applications

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Engineering, Biomedical

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Radiology, Nuclear Medicine & Medical Imaging

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Computer Science

•

Engineering

•

axon

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radius

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mri

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human connectome

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powder averaging

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spherical mean

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spherical harmonics

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restricted diffusion

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tissue-microstructure

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spin-echo

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anisotropy

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density

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distributions

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coefficients

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framework

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model

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LTS5  
Available on Infoscience
June 19, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/198411
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