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review article

Recent progress in alkynylation with hypervalent iodine reagents

Le Du, Eliott  
•
Waser, Jerome  
January 19, 2023
Chemical Communications (ChemComm)

Although alkynes are one of the smallest functional groups, they are among the most versatile building blocks for organic chemistry, with applications ranging from biochemistry to material sciences. Alkynylation reactions have traditionally relied on the use of acetylenes as nucleophiles. The discovery and development of ethynyl hypervalent iodine reagents have allowed to greatly expand the transfer of alkynes as electrophilic synthons. In this feature article the progress in the field since 2018 will be presented. After a short introduction on alkynylation reactions and hypervalent iodine reagents, the developments in the synthesis of alkynyl hypervalent iodine reagents will be discussed. Their recent use in base-mediated and transition-metal catalyzed alkynylations will be described. Progress in radical-based alkynylations and atom-economical transformations will then be presented.

  • Details
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Type
review article
DOI
10.1039/d2cc06168f
Web of Science ID

WOS:000913822400001

Author(s)
Le Du, Eliott  
Waser, Jerome  
Date Issued

2023-01-19

Publisher

Royal Society of Chemistry

Published in
Chemical Communications (ChemComm)
Subjects

Chemistry, Multidisciplinary

•

Chemistry

•

c-h alkynylation

•

catalyzed oxy-alkynylation

•

one-pot synthesis

•

alkynyliodonium salts

•

decarboxylative alkynylation

•

carboxylic-acids

•

terminal alkynes

•

selective synthesis

•

diazo-compounds

•

iodonium salts

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCSO  
Available on Infoscience
February 13, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/194750
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