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  4. Tetracycline derivative induced mitohormesis mediates disease tolerance against viral infections
 
patent

Tetracycline derivative induced mitohormesis mediates disease tolerance against viral infections

Auwerx, Johan  
•
Mottis, Adrienne Joëlle Laurence  
•
Nelson, Mark
2023

The present invention relates to a compound of formula (I) or formula (II) formula (I) formula (II) or a salt thereof for use in treating or preventing a viral disease or viral infection, wherein within formula (I) or (II) (A) A is H or OH, X is CH3, and R1 and R2 are H and R3 is selected from the group consisting of a linear or branched C3 to C8 alkyl, a cycloalkyl, an alkenyl, a phenylalkenyl (preferably styryl), an aryl, and a heteroaryl; or (B) A is H or OH, X is CH3, and R2 is H and R1 and R3 are independently selected from the group consisting of a linear or branched C3 to C8 alkyl, a cycloalkyl, an alkenyl, a phenylalkenyl (preferably styryl), an aryl, and a heteroaryl; or (C) A is H or OH, X is H or CH3, and R1 to R3 are each independently selected from H, F, Cl, Br, or I, provided that at least one of R1 to R3 is F, Cl, Br, or I; or wherein within formula (II) (D) A is H or OH, X is CH3, and R1 to R3 are H, and wherein for (A) and (B) the heteroatom of the heteroaryl is selected from S, O and N, and the linear or branched C3 to C8 alkyl, cycloalkyl, alkenyl, phenylalkenyl (preferably styryl), aryl, and heteroaryl are unsubstituted or are substituted, preferably substituted with one or more of F, Cl, Br, I, -OH, -SH, -NH2, -N3, -NO2, - CN, -CHO, -COOH, or -CONH2 and more preferably with one or more F or Br.

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Type
patent
EPO Family ID

76695612

Author(s)
Auwerx, Johan  
•
Mottis, Adrienne Joëlle Laurence  
•
Nelson, Mark
Note

Alternative title(s) : (de) Tetracyclinderivat-induzierte mitohormese zur vermittlung von krankheitstoleranz gegen virale infektionen (fr) Mitohormèse induite par un dérivé de la tétracycline modifiant la tolérance à la maladie contre les infections virales

TTO classification

TTO:6.2156

EPFL units
AVP-R-TTO  
DOICountry codeKind codeDate issued

EP4362953

EP

A1

2024-05-08

WO2023274941

WO

A1

2023-01-05

EP4112058

EP

A1

2023-01-04

Available on Infoscience
February 6, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/194638
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