Recombinant bacteria resistant to horizontal gene transfer and phage infection
The invention relates to an expression vector encoding a DNA defence system comprising polypeptides derived from Vibrio cholerae, or equivalent functional variants or homologues, conferring resistance to the maintenance of extra-genomic DNA to a recipient bacterial cell. The invention further relates to methods for obtaining an isolated bacterium, or a bacterial population capable of eliminating extra-genomic DNA, or of protecting against phage infection, and an isolated bacterium, or a product comprising an expression vector according to the invention.
77042683
Alternative title(s) : (fr) Bactéries recombinées résistantes au transfert horizontal de gènes et à l'infection phagique
TTO:6.2175
Patent number | Country code | Kind code | Date issued |
WO2023275328 | WO | A1 | 2023-01-05 |