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  4. The kinectome: A comprehensive kinematic map of human motion in health and disease
 
research article

The kinectome: A comprehensive kinematic map of human motion in health and disease

Troisi Lopez, Emahnuel
•
Sorrentino, Pierpaolo
•
Liparoti, Marianna
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July 15, 2022
Annals Of The New York Academy Of Sciences

Human voluntary movement stems from the coordinated activations in space and time of many musculoskeletal segments. However, the current methodological approaches to study human movement are still limited to the evaluation of the synergies among a few body elements. Network science can be a useful approach to describe movement as a whole and to extract features that are relevant to understanding both its complex physiology and the pathophysiology of movement disorders. Here, we propose to represent human movement as a network (that we named the kinectome), where nodes represent body points, and edges are defined as the correlations of the accelerations between each pair of them. We applied this framework to healthy individuals and patients with Parkinson's disease, observing that the patients' kinectomes display less symmetrical patterns as compared to healthy controls. Furthermore, we used the kinectomes to successfully identify both healthy and diseased subjects using short gait recordings. Finally, we highlighted topological features that predict the individual clinical impairment in patients. Our results define a novel approach to study human movement. While deceptively simple, this approach is well-grounded, and represents a powerful tool that may be applied to a wide spectrum of frameworks.

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Type
research article
DOI
10.1111/nyas.14860
Web of Science ID

WOS:000825378900001

Author(s)
Troisi Lopez, Emahnuel
Sorrentino, Pierpaolo
Liparoti, Marianna
Minino, Roberta
Polverino, Arianna
Romano, Antonella
Carotenuto, Anna
Amico, Enrico  
Sorrentino, Giuseppe
Date Issued

2022-07-15

Publisher

WILEY

Published in
Annals Of The New York Academy Of Sciences
Subjects

Multidisciplinary Sciences

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Science & Technology - Other Topics

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gait analysis

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movement pattern

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network

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parkinson's disease

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parkinsons-disease

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trunk

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walking

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stability

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variability

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progression

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impairment

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asymmetry

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people

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
MIPLAB  
Available on Infoscience
August 1, 2022
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/189711
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