One of the most alarming recent findings in geo-science is the dramatic rise in the rate of humaninduced earthquakes in the past decade. This is due to the fluid injection or extraction in deep reservoirs for hydrocarbon production, wastewater and CO2 storage and exploitation of geothermal resources which result in the reactivation of nearby faults. These reservoirs are often located 2-3 km depth (i.e. 30 MPa), and are hosted in or covered by sedimentary carbonate layers. As carbonate undergoes a brittle-ductile transition with increasing confining pressure from values of around 20 MPa, ductile deformation can play an important role on the nucleation and propagation of earthquakes on carbonate faults. Here, we investigate the role of increasing ductile behaviour on fault frictional parameters. The research is performed through the new biaxial apparatus installed at EPFL, the HighSTEPS (High Strain TEmperature Pressure Speed) apparatus, able to measure frictional parameters in a wide range of shearing velocities (10-6 m/s – 0.2 m/s) and under unique boundary conditions representative of the Earth’s crust, i.e., normal stress up to 100 MPa, confining pressure up to 100 MPa, pore fluid pressure up to 100 MPa and temperature up to 120°. The induced stress state in bare surface samples was previously studied by a comparison between results of FEM numerical analyses and experimental ones. Under shear loading conditions, the principal stress σ1 is oriented at about 25° to the vertical axis, and the confining pressure corresponds to the principal stress σ2. Tests are performed under different values of applied confining pressure (1 - 60 MPa) and normal stress (1.5 – 90 MPa) on the faults, keeping constant the ratio between σn/σ3 around ~ 3, to mimic faults at different depth. We present experimental results mapping carbonate fault mechanical behaviour from low shearing velocity 10-6 m/s to high shearing velocity 10-1 m/s. Moreover, experimental results are modelled with rate-and-state friction laws (RSFLs) to define rate and state parameters related to the critical conditions for fault stability and its dependence on the presence of ductile deformation. These results shed new light on the nucleation and propagation of earthquake within the brittle-ductile transition in carbonate bearing rocks.