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research article
Genomic studies indicate a novel combination therapy for follicular lymphoma COMMENT
November 2, 2021
Follicular lymphoma (FL) is an incurable form of B-cell lymphoma. Genomic alterations that inactivate RB signaling are surprisingly common in indolent FL. We show that FLs that are positive for phosphorylated RB respond to dual CDK4/BCL2 inhibition. Our results imply that RB phosphorylation identifies patients likely to benefit from such dual intervention.
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Type
research article
Web of Science ID
WOS:000744289300017
Authors
Publication date
2021-11-02
Publisher
Published in
Volume
8
Issue
6
Article Number
e969640
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
January 29, 2022