European energy policies are aimed at increasing the climate resilience of infrastructure, including new and existing buildings. The implications of future ambient conditions on the energy and environmental performance in buildings and respective adaptation strategies still need to be thoroughly investigated. The aim of this simulation-based study is to estimate the effect of selected future weather scenarios by the Intergovernmental Panel on Climate change (IPCC), on the energy demand of a Swiss office building. The results showed that the cooling demand can increase up to 146% in future scenarios. Finally, some preliminary alternative design and operational solutions were explored to enhance building resilience to climate change.