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research article

Mathematical and numerical models for the cardiac electromechanical function

Dede, Luca
•
Quarteroni, Alfio  
•
Regazzoni, Francesco
January 1, 2021
Rendiconti Lincei-Matematica E Applicazioni

This paper deals with the mathematical model that describes the function of the human heart. More specifically, it addresses the equations that express the electromechanical process, that is the mechanical deformation (contraction and relaxation) of the heart muscle that is induced by the electrical field that, at every heartbeat, is generated in the sino-atrial node and then propagates all across the cardiac cells. After deriving the equations of the mathematical model from basic physical principles, we proceed to their numerical approximations and discuss issues such as stability, accuracy and computational complexity. We close the paper by illustrating a few numerical results on test problems of potential interest for clinical applications.

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Type
research article
DOI
10.4171/RLM/935
Web of Science ID

WOS:000675597600004

Author(s)
Dede, Luca
Quarteroni, Alfio  
Regazzoni, Francesco
Date Issued

2021-01-01

Publisher

EUROPEAN MATHEMATICAL SOC-EMS

Published in
Rendiconti Lincei-Matematica E Applicazioni
Volume

32

Issue

2

Start page

233

End page

272

Subjects

Mathematics, Applied

•

Mathematics

•

mathematical modelling

•

cardiac function

•

active force generation

•

numerical approximation

•

multiphysics modelling

•

cooperative activation

•

tropomyosin overlap

•

muscle-contraction

•

bidomain model

•

active-strain

•

myocardium

•

dynamics

•

calcium

•

myosin

•

framework

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CMCS  
Available on Infoscience
July 31, 2021
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/180276
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