Objective.Body-Machine Interfaces (BoMIs) establish a way to operate a variety of devices, allowing their users to extend the limits of their motor abilities by exploiting the redundancy of muscles and motions that remain available after spinal cord injury or stroke. Here, we considered the integration of two types of signals, motion signals derived from inertial measurement units (IMUs) and muscle activities recorded with electromyography (EMG), both contributing to the operation of the BoMI.Approach.A direct combination of IMU and EMG signals might result in inefficient control due to the differences in their nature. Accordingly, we used a nonlinear-regression-based approach to predict IMU from EMG signals, after which the predicted and actual IMU signals were combined into a hybrid control signal. The goal of this approach was to provide users with the possibility to switch seamlessly between movement and EMG control, using the BoMI as a tool for promoting the engagement of selected muscles. We tested the interface in three control modalities, EMG-only, IMU-only and hybrid, in a cohort of 15 unimpaired participants. Participants practiced reaching movements by guiding a computer cursor over a set of targets.Main results.We found that the proposed hybrid control led to comparable performance to IMU-based control and significantly outperformed the EMG-only control. Results also indicated that hybrid cursor control was predominantly influenced by EMG signals.Significance.We concluded that combining EMG with IMU signals could be an efficient way to target muscle activations while overcoming the limitations of an EMG-only control.