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review article
The emerging landscape of single-molecule protein sequencing technologies
June 7, 2021
Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not yet established. Here we describe new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling. These technologies will in turn facilitate biological discovery and open new avenues for ultrasensitive disease diagnostics.
Type
review article
Authors
Alfaro, Javier Antonio
•
Bohländer, Peggy
•
Dai, Mingjie
•
Filius, Mike
•
Howard, Cecil J.
•
van Kooten, Xander F.
•
Ohayon, Shilo
•
Pomorski, Adam
•
Schmid, Sonja
•
Aksimentiev, Aleksei
Publication date
2021-06-07
Published in
Volume
18
Issue
6
Start page
604
End page
617
Peer reviewed
REVIEWED
EPFL units
Funder | Grant Number |
Other foundations | 8060 Peter and Traudl Engelhorn Foundation |
Available on Infoscience
June 7, 2021
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