Particle release from human skin and clothing has been identified as an important contributor to particulate matter burden indoors. However, knowledge about modeling the coarse particle release from skin and clothing is limited. This study developed a new empirically validated CFD modeling methodology for particle release and transport from seated occupants in an office setting. We tested three modeling approaches for particle emissions: Uniform; Uniform + Localized; and Uniform + Localized with Body Motion; applied to four office scenarios involving a single occupant and two occupants facing each other at 1- and 2-m distances. Uniform particle emissions from skin and clothing underpredicted personal inhalation exposure by as much as 55%-80%. Combining uniform with localized emissions from the armpits drastically reduced the error margin to <10%. However, this modeling approach heavily underestimated particle mass exchange (cross-contamination) between the occupants. Accounting for the occupant's body motion-by applying the momentum theory method-yielded the most accurate personal exposure and cross-contamination results, with errors below 12%. The study suggests that for accurate modeling of particle release and transport from seated occupants indoors, localized body emissions in combination with simplified bodily movements need to be taken into account.