The spatial organization of cGAS-TREX1 interactions
Juricic, Paula; Ablasser, Andrea
2021

Abstract

Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021) and Zhou et al. (2021), uncover new aspects of this important control mechanism.

Details

Title The spatial organization of cGAS-TREX1 interactions
Author(s) Juricic, Paula ; Ablasser, Andrea
Published in Developmental Cell
Volume 56
Issue 7
Pages 876-877
Date 2021-04-05
Publisher Cambridge, CELL PRESS
ISSN 1534-5807
1878-1551
Keywords
DOI https://doi.org/10.1016/j.devcel.2021.03.016
Other identifier(s) View record in Web of Science
Laboratories UPABLASSER
Record Appears in Scientific production and competences > SV - School of Life Sciences > GHI - Global Health Institute > UPABLASSER - Prof. Ablasser Group
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2021-05-22