Polyelemental compounds with dimensions in the nanosized regime are desirable in a large variety of applications, yet their synthesis remains a general challenge in chemistry. One of the major bottlenecks to obtaining multinary systems is the complexity of the synthesis itself. As the number of elements to include in one single nano-object increases, different chemical interactions arise during nudeation and growth, thus challenging the formation of the targeted product. Choosing the reaction conditions and identifying the parameters which ensure the desired reaction pathway are of the uttermost importance. When, in addition to composition, the simultaneous control of size and shape is sought after, the development of new synthetic strategies guided by the fundamental understanding of the formation mechanisms becomes crucial. In this Account we discuss the use of colloidal chemistry to target multinary oxide nanomaterials, with focus on light absorbers which can drive chemical reactions. We propose the combination of soft and solid-state chemistries as one successful strategy to target this family of polyelemental compounds with control on composition and morphological features. To start with, we highlight studies where in situ forming nanoparticles act as reaction intermediates, which we found in both oxide (i.e., Bi-V-O) and sulfide (Cu-M-S, with M = V, Cr, Mn) nanocrystals (NCs). Examples of ternary sulfides are mentioned only with the purpose of showing that similar mechanisms can apply to different families of multinary nanomaterials. Using this new knowledge, we demonstrate that reacting pre-synthesized NCs with well-defined composition and size with molecular precursors allows significant control of these same property-dictating features (i.e., composition and grain size) in the resulting ternary and quaternary compounds. For example, nanostructured BiV1-xSbxO4 thin films with tunable composition and nanostructured beta-Cu2V2O7 with tunable grain size were accessed from colloidally synthesized Bi1-xSbxNCs (0 < x < 1) and sizecontrolled Cu NCs reacted with a vanadium molecular precursor, respectively. The analysis of reaction aliquots revealed that the formation of these materials occurs via a solid-state reaction between the NC precursors and V-containing amorphous nanoparticles, which form in situ from the molecular precursors. With the aim to achieve better control on the reaction product, we finally propose the use of colloidally synthesized NCs as reactants in solid state reactions. As the first proof of concept, ternary metal oxide NCs, including CuFe2O4, CuMn2O4, and CuGa2O4 with defined size and shape regulated by the NC precursors were obtained. Considering the huge library of single component and binary NCs accessible by colloidal chemistry, the extension of this synthetic concept, which combines soft and solid-state chemistries, to a larger variety of polyelemental nanomaterials is foreseen. Such an approach will contribute to facilitate a more rapid translation of design principles to materials with the desired composition and structural features.