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research article
Small peptide diversification through photoredox-catalyzed oxidative C-terminal modification
January 7, 2021
A photoredox-catalyzed oxidative decarboxylative coupling of small peptides is reported, giving access to a variety of N,O-acetals. They were used as intermediates for the addition of phenols and indoles, leading to novel peptide scaffolds and bioconjugates. Amino acids with nucleophilic side chains, such as serine, threonine, tyrosine and tryptophan, could also be used as partners to access tri- and tetrapeptide derivatives with non-natural cross-linking.
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Name
CS2021-2467GoldAccess.pdf
Type
Publisher's version
Access type
openaccess
License Condition
CC BY
Size
10.54 MB
Format
Adobe PDF
Checksum (MD5)
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