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research article
Synthesis of Thiochromans via [3+3] Annulation of Aminocyclopropanes with Thiophenols
November 20, 2020
We report the one-pot synthesis of 4-amino thiochromans using simple aminocyclopropanes and thiophenols through a formal [3+3] annulation reaction. This reaction proceeds under mild conditions with good functional group tolerance. The thiochroman core was formed with complete regioselectivity, and modification of complex drug molecules containing an aminocyclopropane was also realized.
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Name
OL2020-4517GreenAccess1.pdf
Type
Preprint
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openaccess
License Condition
CC BY-NC
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6.3 MB
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Adobe PDF
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9688a31ddf7168eac86a6d61d53f8035
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Name
OL2020-4517GreenAccess.pdf
Type
Postprint
Access type
embargo
Embargo End Date
2021-11-10
License Condition
CC BY-NC
Size
6.28 MB
Format
Adobe PDF
Checksum (MD5)
9aa3b2b7749f049693f6c42423afd2f8