A search for the doubly heavy Xi bc0 baryon using its decay to the D(0)pK(-) final state is performed using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the LHCb experiment between 2016 and 2018, corresponding to an integrated luminosity of 5.4 fb(-1). No significant signal is found in the invariant mass range from 6.7 to 7.2 GeV/c(2). Upper limits are set at 95% credibility level on the ratio of the Xi bc0 production cross-section times its branching fraction to D(0)pK(-) relative to that of the Lambda b0 -> D0pK- decay. The limits are set as a function of the Xi bc0 mass and lifetime hypotheses, in the rapidity range from 2.0 to 4.5 and in the transverse momentum region from 5 to 25 GeV/c. Upper limits range from 1.7 x 10(-2) to 3.0 x 10(-1) for the considered Xi bc0 mass and lifetime hypotheses.