Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Needle-free delivery of fluids from compact laser-based jet injector
 
research article

Needle-free delivery of fluids from compact laser-based jet injector

Krizek, Jan  
•
De Goumoens, Frederic
•
Delrot, Paul  
Show more
October 21, 2020
Lab On A Chip

Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Due to bulky actuation mechanisms, they are limited to body areas that are easy to reach such as skin. Here, we demonstrate a thin and long liquid delivery system (e.g.flexible and 30 cm long with 1.2 mm outer diameter) compatible with minimally invasive surgical procedures. The actuation mechanism is based on optical cavitation in a capillary nozzle where a laser pulse is deliveredviaa multimode optical fibre. We show good controllability of the jet speed by varying the actuation laser fluence. The generated jets can successfully penetrate into a 1% agarose gel which is representative of the mechanical properties of several soft body tissues. We further observe that when the system is used in a low laser energy regime (<60 mu J), the ejection is in the form of the single droplet which is promising for fluid delivery with high volume precision or drop-on-demand inkjet printing. The jet injection system we propose has the potential to deliver heat-sensitive therapeutics as we show processing of biomolecules without altering their functionality.

  • Details
  • Metrics
Type
research article
DOI
10.1039/d0lc00646g
Web of Science ID

WOS:000577744000007

Author(s)
Krizek, Jan  
De Goumoens, Frederic
Delrot, Paul  
Moser, Christophe  
Date Issued

2020-10-21

Published in
Lab On A Chip
Volume

20

Issue

20

Start page

3784

End page

3791

Subjects

Biochemical Research Methods

•

Chemistry, Multidisciplinary

•

Chemistry, Analytical

•

Nanoscience & Nanotechnology

•

Instruments & Instrumentation

•

Biochemistry & Molecular Biology

•

Chemistry

•

Science & Technology - Other Topics

•

induced plasma formation

•

microjet

•

water

•

skin

•

penetration

•

nanosecond

•

stability

•

dynamics

•

devices

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
DCG  
Available on Infoscience
October 29, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/172840
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés