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  4. The additive hazard estimator is consistent for continuous-time marginal structural models
 
research article

The additive hazard estimator is consistent for continuous-time marginal structural models

Ryalen, Pål C.
•
Stensrud, Mats J.
•
Røysland, Kjetil
October 1, 2019
Lifetime Data Analysis

Marginal structural models (MSMs) allow for causal analysis of longitudinal data. The standard MSM is based on discrete time models, but the continuous-time MSM is a conceptually appealing alternative for survival analysis. In applied analyses, it is often assumed that the theoretical treatment weights are known, but these weights are usually unknown and must be estimated from the data. Here we provide a sufficient condition for continuous-time MSM to be consistent even when the weights are estimated, and we show how additive hazard models can be used to estimate such weights. Our results suggest that continuous-time weights perform better than IPTW when the underlying process is continuous. Furthermore, we may wish to transform effect estimates of hazards to other scales that are easier to interpret causally. We show that a general transformation strategy can be used on weighted cumulative hazard estimates to obtain a range of other parameters in survival analysis, and explain how this strategy can be applied on data using our R packages ahw and transform.hazards.

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Type
research article
DOI
10.1007/s10985-019-09468-y
Author(s)
Ryalen, Pål C.
Stensrud, Mats J.
Røysland, Kjetil
Date Issued

2019-10-01

Published in
Lifetime Data Analysis
Volume

25

Issue

4

Start page

611

End page

638

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
BIOSTAT  
Available on Infoscience
October 15, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/172534
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