Catalytic Enantioselective Synthesis and Switchable Chiroptical Property of Inherently Chiral Macrocycles

We report herein a strategy to construct enantiopure inherently chiral macrocycles, ABCD-type heteracalix[4]-aromatics, through a catalytic enantioselective intramolecular C−N bond forming reaction. A chiral ligand-palladium complex was found to efficiently induce the inherent chirality of molecules during the macrocyclization process with ee values up to >99%. The resulting ABCD-type heteracalix[4]aromatics displayed excellent and pH triggered switchable electronic circular dichroism and circularly polarized luminescence properties.


Published in:
Journal of the American Chemical Society, 142, 34, 14432-14436
Year:
2020
Laboratories:




 Record created 2020-09-28, last modified 2020-10-25


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