In this work, we consider the stability of a spherical shell under combined loading from a uniform external pressure and a homogenous natural curvature. Nonmechanical stimuli, such as one that tends to modify the rest curvature of an elastic body, are prevalent in a wide range of natural and engineered systems, and may occur due to thermal expansion, changes in pH, differential swelling, and differential growth. Here we investigate how the presence of both an evolving natural curvature and an external pressure modifies the stability of a complete spherical shell. We show that due to a mechanical analogy between pressure and curvature, positive natural curvatures can severely destabilize a thin shell, while negative natural curvatures can strengthen the shell against buckling, providing the possibility to design shells that buckle at or above the theoretical limit for pressure alone, i.e., a strengthening factor. These results extend directly from the classical analysis of the stability of shells under pressure, and highlight the important role that nonmechanical stimuli can have on modifying the membrane state of stress in a thin shell.