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research article
Asymmetric (CpRh)-Rh-x(III)-Catalyzed Acrylic Acid C-H Functionalization with Allenes Provides Chiral gamma-Lactones
August 7, 2020
A chiral cyclopentadienyl (Cp-x) ligand featuring the semi-saturated H8-binaphthyl backbone as the chiral element was developed. Its application potential was demonstrated by (CpRhIII)-Rh-x-catalyzed C-H bond functionalization of acryl acids and allenes, exhibiting superior catalytic performance compared to other Cp-x ligands. The outlined enantioselective [4 + 1]-annulation process results in synthetically attractive alpha, beta-unsaturated gamma-lactones having an allylic stereogenic center, which were obtained in enantioselectivities of up to 99:1 enantiomeric ratio.
Type
research article
Web of Science ID
WOS:000562075000020
Authors
Publication date
2020-08-07
Publisher
Published in
Volume
10
Issue
15
Start page
8231
End page
8236
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
September 10, 2020
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