Introduction: The unprecedented speed and scale of the COVID-19 pandemic necessitated the rapid implementation of untested public health measures to mitigate the consequences of viral spread. In the 8 months that have passed since the first recognized case, an enormous amount of research has been published evaluating the efficacy of the various policies implemented by different countries, however the majority of these studies focus on a specific region or time, over-representing high-income countries during periods of extreme transmission or “peak events”. The aim of this study is to provide a more general analysis that considers a global scope of the pandemic and the dynamic drivers that build effective policies to mitigate human interactions and slow the spread of disease. Methods: We collected a range of information regarding epidemic trends, weather, demographics, government response and mobility reports across the globe. We then built an hybrid Neural Network that combined an LSTM layer with a multilayer perceptron to infer the reproduction number from various non-epidemiological factors. The model was designed to predict the reproduction number (R-value) on 93 countries with available data and compare it to our ground truth estimate obtained from officially reported epidemiological data. Finally, we used an alternative model to assess the impact of public health measures on the epidemic. Findings: From the available features, we obtained the best performances using demographics combined with mobility features. The sanitary indices (beds/thousand, diabetes prevalence, ...) did not help the prediction and, more interestingly, the pressure indicator of historical weather forecast improved the prediction of the reproduction number by about 4.5%. This optimized model predicted the reproduction number with a mean absolute error of 0.254 across the 93 countries over the time of the epidemic. For many countries (Switzerland, United Kingdom, South Africa, ...) this error passed below 0.17. An alternative version of the model allowed us to estimate the impact of policies in terms of average reduction in reproduction number, and more importantly, allowed us to compare these trends between countries. For instance, we observe that the model showed that no policy had a positive impact in India as opposed to Switzerland, where most of them are associated to improved epidemic control. Conclusion: Understanding these complex interactions may allow individuals and policy makers to better adapt mitigation strategies to optimize the efficacy of the implemented policies.