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research article
Confounding factors from inducible systems for spatiotemporal gene expression regulation
July 6, 2020
Spatiotemporally regulated targeted gene manipulation is a common way to study the effect of gene variants on phenotypic traits, but the Cre/loxP and Tet-On/Tet-Off systems can affect whole-organism physiology and function due to off-target effects. We highlight some of these adverse effects, including whole-body endocrinology and disturbances in the gut microbiome and in mitochondrial and metabolic function.
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jcb_202003031.pdf
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openaccess
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CC BY-NC-SA
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851.11 KB
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Adobe PDF
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