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research article
Three-Component Reaction for the Synthesis of Highly Functionalized Propargyl Ethers
March 18, 2020
Multicomponent reactions provide efficient means to access molecular complexity. Herein, we report a copper-catalyzed three-component reaction of diazo compounds, alcohols and ethynyl benziodoxole (EBX) reagents for the synthesis of propargyl ethers. Extensive variations of the three partners of the reaction is possible, leading to highly functionalized and structurally diverse products under mild conditions. Alkynylation of a copper ylide intermediate is postulated as key step for this transformation.
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Name
CEJ2020-10199GreenAccess.pdf
Type
Postprint
Access type
openaccess
License Condition
CC BY-NC
Size
14.39 MB
Format
Adobe PDF
Checksum (MD5)
904600ffc22707a7bdada482bc9c6290