Comparative characterisation of non-monodisperse gold nanoparticle populations by X-ray scattering and electron microscopy

Accurate nanoparticle size determination is essential across various research domains, with many functionalities in nanoscience and biomedical research being size-dependent. Although electron microscopy is capable of resolving a single particle down to the sub-nm scale, the reliable representation of entire populations is plagued by challenges in providing statistical significance, suboptimal preparation procedures and operator bias. While alternative techniques exist that provide ensemble information in solution, their implementation is generally challenging for non-monodisperse populations. Herein, we explore the use of small-angle X-ray scattering in combination with form-free Monte Carlo fitting of scattering profiles as an alternative to conventional electron microscopy imaging in providing access to any type of core size distribution. We report on a cross-method comparison for quasi-monodisperse, polydisperse and bimodal gold nanoparticles of 2-7 nm in diameter and discuss advantages and limitations of both techniques.


Published in:
Nanoscale, 12, 22, 12007-12013
Year:
Jun 14 2020
ISSN:
2040-3364
2040-3372
Keywords:
Note:
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Laboratories:


Note: The status of this file is: Anyone


 Record created 2020-07-09, last modified 2020-10-23

Final:
Download fulltext
PDF

Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)