Automated High-Content Phenotyping Of The Nematode C. Elegans At Single Animal Resolution With A Microfluidic Platform
In this work, we present a novel microfluidic approach to culture the nematode C. elegans from the onset of embryogenesis to the adult stage at single animal resolution. Our device allows high-throughput experimentation, high-resolution imaging, thereby providing high-content phenotyping in a highly parallel fashion. As a validation study, we studied the dose-dependent influence of the anthelmintic drug, tetramisole on the nematodes' development during their full life cycle. Our results revealed a clear impact of tetramisole on various worm phenotypes.
WOS:000539487000559
2019-01-01
978-1-7281-2007-2
New York
2209
2212
REVIEWED
Event name | Event place | Event date |
Berlin, GERMANY | Jun 23-27, 2019 | |