Soft bioelectronic interfaces are broadly defined as microfabricated devices, distributed over large-areas, and with mechanical properties suited to comply the soft and dynamic biological tissues. The hybrid integration and processing of materials ranging from elastomers to metals lead devices with combined mechanical compliance, electrical function, and (if needed) biocompatibility. Using examples of their use for wearable electronics and biomimetic neural implants, this talk will highlight the unique capabilities of soft bioelectronics, and report on our recent efforts to establish their reliability and lifetime for daily use.