Exploring the interactions between the human and viral genomes

Over the last decade, genome-wide association studies led to major advances in identifying human genetic variants associated with infectious disease susceptibility. On the pathogen side, comparable methods are now applied to identify disease-modulating pathogen variants. As host and pathogen variants jointly determine disease outcomes, the most recent development has been to explore simultaneously host and pathogen genomes, through so-called genome-to-genome studies. In this review, we provide some background on the development of genome-to-genome analysis and we detail the first wave of studies in this emerging field, which focused on patients chronically infected with HIV and hepatitis C virus. We also discuss the need for novel statistical methods to better tackle the issues of population stratification and multiple testing. Finally, we speculate on future research areas where genome-to-genome analysis may prove to be particularly effective.


Published in:
Human Genetics, 139, 6-7, 777-781
Year:
Jun 01 2020
Publisher:
New York, SPRINGER
ISSN:
0340-6717
1432-1203
Keywords:
Laboratories:




 Record created 2020-06-20, last modified 2020-07-01


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