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research article
Will Cryo-Electron Microscopy Shift the Current Paradigm in Protein Structure Prediction?
May 26, 2020
Protein dynamics is undoubtedly a pervasive ingredient in all biological functions. However, structural biology has been strongly driven by a static-centered view of protein architecture. We argue that the recent advances of cryo-electron microscopy (EM) have the potential to more broadly explore the conformational landscapes of protein complexes and therefore will enhance our ability to predict the diverse conformations of tertiary and quaternary protein structures that are functionally relevant in physiological conditions.
Type
research article
Web of Science ID
WOS:000537653400008
Authors
Publication date
2020-05-26
Publisher
Published in
Volume
60
Issue
5
Start page
2443
End page
2447
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
June 18, 2020
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