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  4. Filamentous and step-like behavior of gelling coarse fibrin networks revealed by high-frequency microrheology
 
research article

Filamentous and step-like behavior of gelling coarse fibrin networks revealed by high-frequency microrheology

Dominguez-Garcia, Pablo
•
Dieter, Giovanni
•
Forro, Laszlo  
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May 7, 2020
Soft Matter

By a micro-experimental methodology, we study the ongoing molecular process inside coarse fibrin networks by means of microrheology. We made these networks gelate around a probe microbead, allowing us to observe a temporal evolution compatible with the well-known molecular formation of fibrin networks in four steps: monomer, protofibril, fiber and network. Thanks to the access that optical-trapping interferometry provides to the short-time scale on the bead's Brownian motion, we observe a Kelvin-Voigt mechanical behavior from low to high frequencies, range not available in conventional rheometry. We exploit that mechanical model for obtaining the characteristic lengths of the filamentous structures composing these fibrin networks, whose obtained values are compatible with a non-affine behavior characterized by bending modes. At very long gelation times, a omega (7/8) power-law is observed in the loss modulus, theoretically related with the longitudinal response of the molecular structures.

  • Details
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Type
research article
DOI
10.1039/c9sm02228g
Web of Science ID

WOS:000532303400012

Author(s)
Dominguez-Garcia, Pablo
•
Dieter, Giovanni
•
Forro, Laszlo  
•
Jeney, Sylvia  
Date Issued

2020-05-07

Publisher

ROYAL SOC CHEMISTRY

Published in
Soft Matter
Volume

16

Issue

17

Start page

4234

End page

4242

Subjects

Chemistry, Physical

•

Materials Science, Multidisciplinary

•

Physics, Multidisciplinary

•

Polymer Science

•

Chemistry

•

Materials Science

•

Physics

•

slender-body theory

•

light-scattering

•

mechanical-properties

•

elasticity

•

dynamics

•

microscopy

•

particles

•

actin

•

fiber

•

gels

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LNNME  
LPMC  
Available on Infoscience
May 28, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/168978
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