Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Long-term biointegration of man-made neural interfaces is influenced by the mechanical properties of the implant materials. Substantial experimental work currently aims at replacing conventional hard implant materials with soft alternatives that can favour a lower immune response. Here we assess the performance of a soft electrode array implanted in the spinal epidural space of a minipig model for a period of 6 months. The electrode array includes platinum-silicone electrode contacts and elastic thin-film gold interconnects embedded in silicone. In-vivo electrode impedance and voltage transients were monitored over time. Following implantation, epidural stimulation produced muscle-specific evoked potentials and visible muscle contractions. Over time, postoperative and stimulation induced changes in electrode impedance were observed. Such trends provide a basis for future technological improvements aiming at ensuring the stability of soft implantable electrodes for neural interfacing.


Editor(s):
Schiavone, Giuseppe
Wagner, Fabien
Fallegger, Florian
Kang, Xiaoyang
Vachicouras, Nicolas
Barra, Beatrice
Capogrosso, Marco
Bloch, Jocelyne
Courtine, Grégoire
Lacour, Stéphanie
Published in:
Proceedings of the 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Presented at:
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Year:
2018
Publisher:
IEEE
Other identifiers:
Laboratories:


Note: The status of this file is: Anyone
The status of this file is: EPFL only


 Record created 2020-05-07, last modified 2020-05-11

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