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  4. Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model
 
conference paper

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Schiavone, Giuseppe  
•
Wagner, Fabien  
•
Fallegger, Florian  
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Schiavone, Giuseppe  
•
Wagner, Fabien  
Show more
2018
Proceedings of the 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Long-term biointegration of man-made neural interfaces is influenced by the mechanical properties of the implant materials. Substantial experimental work currently aims at replacing conventional hard implant materials with soft alternatives that can favour a lower immune response. Here we assess the performance of a soft electrode array implanted in the spinal epidural space of a minipig model for a period of 6 months. The electrode array includes platinum-silicone electrode contacts and elastic thin-film gold interconnects embedded in silicone. In-vivo electrode impedance and voltage transients were monitored over time. Following implantation, epidural stimulation produced muscle-specific evoked potentials and visible muscle contractions. Over time, postoperative and stimulation induced changes in electrode impedance were observed. Such trends provide a basis for future technological improvements aiming at ensuring the stability of soft implantable electrodes for neural interfacing.

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