Herein, we highlighted fluorine-anion-modification as a useful method for enhancing OER catalytic activity. Fluorine-anion-doped Ni foam exhibits an almost 10-fold enhancement in OER catalytic activity. Moreover, fluorine-anion-modification could be used as a general method to greatly increase the OER activity of NiAl LDHs. The strongly electronegative F anion is favorable to build weak metal-fluorine bonds, which easily break to form active species of nickel oxides/hydroxides, enhancing OER catalytic performance.