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  4. A Proof of Concept for Computational Fluid Dynamic Analysis of the Left Atrium in Atrial Fibrillation on a Patient-Specific Basis
 
research article

A Proof of Concept for Computational Fluid Dynamic Analysis of the Left Atrium in Atrial Fibrillation on a Patient-Specific Basis

Masci, Alessandro
•
Alessandrini, Martino
•
Forti, Davide  
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January 1, 2020
Journal Of Biomechanical Engineering-Transactions Of The Asme

Atrial fibrillation (AF) is associated with a fivefold increase in the risk of cerebrovascular events, being responsible of 15-18% of all strokes. The morphological and functional remodeling of the left atrium (LA) caused by AF favors blood stasis and, consequently, stroke risk. In this context, several clinical studies suggest that the stroke risk stratification could be improved by using hemodynamic information on the LA and the left atrial appendage (LAA). The goal of this study was to develop a personalized computational fluid dynamics (CFD) model of the LA which could clarify the hemodynamic implications of AF on a patient-specific basis. In this paper, we present the developed model and its application to two AF patients as a preliminary advancement toward an optimized stroke risk stratification pipeline.

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Type
research article
DOI
10.1115/1.4044583
Web of Science ID

WOS:000522956400010

Author(s)
Masci, Alessandro
Alessandrini, Martino
Forti, Davide  
Menghini, Filippo  
Dede, Luca
Tomasi, Corrado
Quarteroni, Alfio
Corsi, Cristiana
Date Issued

2020-01-01

Publisher

ASME

Published in
Journal Of Biomechanical Engineering-Transactions Of The Asme
Volume

142

Issue

1

Article Number

011002

Subjects

Biophysics

•

Engineering, Biomedical

•

Engineering

•

navier-stokes equations

•

stroke

•

risk

•

management

•

rhythm

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CMCS  
Available on Infoscience
April 17, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/168228
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