This study presents a novel set-up for desiccant-based cooling and dehumidification systems. In this cycle, a solid desiccant and conventional combined cooling and power (CCP) systems, based on the ejector refrigeration cycle (ERC) and the organic Rankine cycle (ORC), are integrated to provide dehumidification and cooling, simultaneously. The ERC is integrated with the ORC for devising a self-powered design which has not been done until now. The proposed integrated system is useful for replacing the peak electricity demand with the heat demand, decreasing the pressure on the power grid in humid areas. Dynamic hourly simulation of the proposed system as well as a conventional system were performed to show the energy saving potential of the proposed system.