In the scope of the Human Brain Project (SGA2), this document summarizes from the technical perspective the main challenges faced by the current Medical Informatics Platform for the integration of three new types of data: complex neuroimaging, omics, and data from wearable devices. Details are discussed up to the implementation level, considering risks, costs, and possible ethical and data privacy issues. The specific recommendations for the future development of the MIP are collected in the accompanying document “Recommendations for the MIP technical development during SGA3”, with component ID C2976.