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research article

Homonuclear Decoupling in H-1 NMR of Solids by Remote Correlation

Moutzouri, Pinelopi  
•
Paruzzo, Federico M.  
•
de Almeida, Bruno Simoes  
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February 19, 2020
Angewandte Chemie International Edition

The typical linewidths of H-1 NMR spectra of powdered organic solids at 111 kHz magic-angle spinning (MAS) are of the order of a few hundred Hz. While this is remarkable in comparison to the tens of kHz observed in spectra of static samples, it is still the key limit to the use of H-1 in solid-state NMR, especially for complex systems. Here, we demonstrate a novel strategy to further improve the spectral resolution. We show that the anti-z-COSY experiment can be used to reduce the residual line broadening of H-1 NMR spectra of powdered organic solids. Results obtained with the anti-z-COSY sequence at 100 kHz MAS on thymol, beta-AspAla, and strychnine show an improvement in resolution of up to a factor of two compared to conventional spectra acquired at the same spinning rate.

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