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research article
Synthesis and chemical transformations of diazolyl alpha,alpha-difluoroacetates
January 1, 2020
Optimized protocols for the synthesis of diazolyl alpha,alpha-difluoroacetates via deoxofluorination of the corresponding glyoxylates with Morph-DAST are described. The method allowed the preparation of the title fluoridated building blocks in 73-96 % yield on up to 15 g scale. Utility of the hetaryl alpha,alpha-difluoroacetates was demonstrated by the synthesis of advanced building blocks for medicinal chemistry, i.e. carboxylic acids, amides, nitriles, and alcohols.
Use this identifier to reference this record
Type
research article
Web of Science ID
WOS:000509631900009
Authors
Geraschenko, Oleksandr V.
•
Solomin, Vitalii V.
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Vashchenko, Bohdan V.
•
•
Tolmachev, Andrey A.
•
Grygorenko, Oleksandr O.
Publication date
2020-01-01
Publisher
Published in
Volume
229
Article Number
109407
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
March 3, 2020