Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Photocontrolled release of the anticancer drug chlorambucil with caged harmonic nanoparticles
 
research article

Photocontrolled release of the anticancer drug chlorambucil with caged harmonic nanoparticles

Vuilleumier, Jérémy  
•
Gaulier, Geoffrey
•
De Matos, Raphaël  
Show more
2020
Helvetica Chimica Acta

While chemotherapy is one of the most used treatments in oncology, the systemic administration of chemotherapeutics generally results in undesired damages to healthy tissues and cells, side effects such as severe nausea and leukopenia, and reduced efficacy due to multidrug resistance and poor target accessibility. The limitations of conventional chemotherapy formulation has prompted the development of alternative nanomaterials-based strategies to achieve targeted and stimuli sensitive payload delivery to reach optimal local drug concentration at tumor sites. In this study, the anticancer drug chlorambucil (Clb) was conjugated to the surface of silica coated lithium niobate (LNO) harmonic nanoparticles (HNPs) using a photocaging tether based on coumarin-4-yl methyl derivative. Upon laser pulsed femtosecond irradiation at 790 nm, the second harmonic emission from the metal oxide core induced the efficient release of Clb, with concomitant contribution from the nonlinear absorption of the coumarin (CM)-based moiety.

  • Details
  • Metrics
Type
research article
DOI
10.1002/hlca.201900251
Author(s)
Vuilleumier, Jérémy  
Gaulier, Geoffrey
De Matos, Raphaël  
Mugnier, Yannick
Campargue, Gabriel
Wolf, Jean-Pierre
Bonacina, Luigi  
Gerber-Lemaire, Sandrine  
Date Issued

2020

Publisher

Wiley-VHCA AG

Published in
Helvetica Chimica Acta
Volume

103

Article Number

e1900251

Subjects

chlorambucil

•

harmonic nanoparticles

•

NIR-light triggered delivery

•

photosensitive tether

•

second harmonic emission

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SCI-SB-SG  
Available on Infoscience
December 27, 2019
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/164221
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés