The simulation of the passage of particles through matter using Monte Carlo methods is broadly used in the development of particle detectors for high energy physics experiments. To develop the readout electronics for the Compact Muon Solenoid (CMS) experiment at CERN, and to assist the design of the on-detector ASICs, a simulation framework was build capable to link the physics Monte Carlo simulations platforms with an industry standard EDA simulation tools. This contribution focuses on the implementation of the simulation framework based on the System Verilog language and the Universal Verification Methodology (UVM). The simulation results that guided the development of the ASICs and the choice of the final architecture are presented.