Novel osmium(II)-cymene complexes containing curcumin and bisdemethoxycurcumin ligands
Pettinari, Riccardo; Marchetti, Fabio; Di Nicola, Corrado; Pettinari, Claudio; Cuccioloni, Massimiliano; Bonfili, Laura; Eleuteri, Anna Maria; Therrien, Bruno; Batchelor, Lucinda K.; Dyson, Paul J.
2019

Abstract

The first examples of (arene)Os(II) curcuminoid derivatives have been prepared and characterized. The neutral complexes [(p-cym)Os(curc)Cl] (1) and [( p-cym)Os(bdcurc)Cl] ( 2), together with the cationic derivatives [( p-cym)Os(curc)(PTA)][SO3CF3] (3) and [( p-cym)Os(bdcurc)(PTA)][SO3CF3] (4) (PTA = 1,3,5-triaza-7-phosphaadamantane) were characterized by NMR spectroscopy and ESI mass spectrometry, and the crystal structure of 1 was determined by X-ray diffraction analysis. The cytotoxicity of the complexes was evaluated in vitro against human ovarian carcinoma cells (A2780 and A2780cisR), as well as against non-tumorous Human Embryonic Kidney cells (HEK293). Binding of the complexes to potential pharmacological targets and serum carriers was also explored.

Details

Title Novel osmium(II)-cymene complexes containing curcumin and bisdemethoxycurcumin ligands
Author(s) Pettinari, Riccardo ; Marchetti, Fabio ; Di Nicola, Corrado ; Pettinari, Claudio ; Cuccioloni, Massimiliano ; Bonfili, Laura ; Eleuteri, Anna Maria ; Therrien, Bruno ; Batchelor, Lucinda K. ; Dyson, Paul J.
Published in Inorganic Chemistry Frontiers
Volume 6
Issue 9
Pages 2448-2457
Date 2019-09-01
Publisher Cambridge, ROYAL SOC CHEMISTRY
ISSN 2052-1553
Keywords
DOI https://doi.org/10.1039/c9qi00843h
Other identifier(s) View record in Web of Science
Laboratories LCOM
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2019-11-05

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