Functional Models of the Nickel Pincer Nucleotide Cofactor of Lactate Racemase
2019
Abstract
A novel nickel pincer cofactor was recently discovered in lactate racemase. Reported here are three synthetic nickel pincer complexes that are both structural and functional models of the pincer cofactor in lactate racemase. DFT computations suggest the ipso-carbon atom of the pyridinium pincer ligands act as a hydride acceptor for lactate isomerization, whereas an organometallic pathway involving nickel-mediated beta-hydride elimination is less favored.
Details
Title
Functional Models of the Nickel Pincer Nucleotide Cofactor of Lactate Racemase
Author(s)
Shi, Renyi ; Wodrich, Matthew D. ; Pan, Hui-Jie ; Tirani, Farzaneh Fadaei ; Hu, Xile
Published in
Angewandte Chemie-International Edition
Volume
58
Issue
47
Pages
16869-16872
Date
2019-10-11
Publisher
Weinheim, WILEY-V C H VERLAG GMBH
ISSN
1433-7851
1521-3773
1521-3773
Keywords
Other identifier(s)
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Record Appears in
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSCI - Laboratory of Inorganic Synthesis and Catalysis
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCMD - Laboratory of Computational Molecular Design
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCMD - Laboratory of Computational Molecular Design
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2019-10-24