Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.


Published in:
Nature Communications, 10, 3193
Year:
Jul 19 2019
Publisher:
London, Springer
ISSN:
2041-1723
Keywords:
Note:
This article is licensed under a Creative Commons Attribution 4.0 International License
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Note: The status of this file is: Anyone


 Record created 2019-08-03, last modified 2020-10-25

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