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research article
C-Terminal Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative Alkynylation
April 18, 2019
We report the first decarboxylative alkynylation of the C-terminus of peptides starting from free carboxylic acids. The reaction is fast, metal-free, and proceeds cleanly to afford alkynylated peptides with a broad tolerance for the C-terminal amino acid. By the use of hypervalent iodine reagents, the introduction of a broad range of functional groups was successful. C-terminal selectivity was achieved by differentiation of the oxidation potentials of the carboxylic acids based on the use of fine-tuned organic dyes.
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ACIE2019-8182GreenAccess.pdf
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embargo
Embargo End Date
2020-04-18
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CC BY-NC
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10.91 MB
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Adobe PDF
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