Reservoir sedimentation and consequently lack of storage volume and perturbation of the operation of intakes and bottom outlet is a key challenge affecting both hydropower production as well as dam safety and flood management. In the framework of a peer-reviewed research project (Jenzer-Althaus, 2011) an innovative countermeasure, called SEDMIX, was proposed allowing to keep in suspension or re-suspend the fine particles near the power water intakes, thanks to an optimized arrangement of four water jets producing an upward whirling flow like produced by a mixer. With such a system, the suspended particles can be conveyed downstream at acceptable rates through the power waterways during the normal operation of the hydropower plant. Although experimental studies have shown the very promising efficiency of such a device in simple cases and by numerical simulations in a laboratory reservoir, SEDMIX performance has not been investigated yet in a real-life reservoir under prototype conditions. The aim of this study is therefore, to analyze the performance of a real-sized SEDMIX operating in the future Trift reservoir via numerical analyses. This study allows to validate or to improve SEDMIX optimal configuration experimentally determined. The numerical simulations are performed for different positions and heights for the SEDMIX device. The performance of SEDMIX in each position has been evaluated and tested for different jet discharges. The analysis of the numerical simulation results shows that the presence of SEDMIX does create a vortex flow pattern and sediment movement upward. The sediment volume fraction in the higher layers of the reservoir increases and consequently the evacuated volume of fin sediments increases for simulation using the SEDMIX device comparing those without the device.