Two-photon triggered photorelease of caged compounds from multifunctional harmonic nanoparticles

The design of stimuli-responsive nanocarriers has raised much attention to achieve higher local concentration of therapeutics and mitigate the appearance of drug resistance. The combination of imaging properties and controlled photorelease of active molecules within the same nanoconjugate has a great potential for theranostic applications. In this study, a system for NIR light-triggered release of molecular cargos induced by the second harmonic emission from bismuth ferrite harmonic nanoparticles (BFO HNPs) is presented. Silica coated BFO HNPs were covalently conjugated to a photocaging tether based on coumarin (CM) and L-Tryptophan (Trp) as model molecular cargo. Upon femtosecond pulsed irradiation at 790 nm, Trp was efficiently released from the NPs surface in response to the harmonic emission of the nanomaterial at 395 nm. The emitted signal induced the photocleavage of the CM-Trp carbamate linkage resulting in the release of Trp, which was monitored and quantified by ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC-MS). While a small fraction of the uncaging process could be attributed to the nonlinear absorption of CM derivatives, the main trigger responsible for Trp release was established as the second harmonic signal from BFO HNPs. This strategy may provide a new way for the application of functionalized HNPs in dual imaging-delivery theranostic protocols.


Published in:
ACS Applied Materials & Interfaces, 11, 27443-27452
Year:
Jul 05 2019
Keywords:
Laboratories:




 Record created 2019-07-09, last modified 2019-10-07


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)